ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TLK2

Full Name:

tousled-like kinase 2

Alias:

MGC44450|PKU-ALPHA

Organism:

Homo sapiens (Human)

Chromosome:

17

Genetic Location:

17q23

Physical Location:

57910135-58044758 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AB004884
Fold Change:		-1.9, -1.5
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006852.3	NP_006843.2	NC_000017.9 range: 57910135..58044758

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS
GO:0005634	nucleus	Cellular Component	IEP (9427565)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (12660173)
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	NAS (9427565\|10523312)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (12660173)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0001672	regulation of chromatin assembly or disassembly	Biological Process	IDA (12660173)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (12660173)
GO:0006974	response to DNA damage stimulus	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IDA (12660173)
GO:0016568	chromatin modification	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000146872

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: