ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

UBE2C

Full Name:

ubiquitin-conjugating enzyme E2C

Alias:

UBCH10|dJ447F3.2

Organism:

Homo sapiens (Human)

Chromosome:

20

Genetic Location:

20q13.12

Physical Location:

43874661-43879002 on NC_000020.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D20S119

43082264

Region:		41082264-45082264
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007019.2	NP_008950.1	NC_000020.9 range: 43874661..43879002
NM_181799.1	NP_861515.1	NC_000020.9 range: 43874661..43879002
NM_181800.1	NP_861516.1	NC_000020.9 range: 43874661..43879002
NM_181801.1	NP_861517.1	NC_000020.9 range: 43874661..43879002
NM_181802.1	NP_861518.1	NC_000020.9 range: 43874661..43879002
NM_181803.1	NP_861519.1	NC_000020.9 range: 43874661..43879002

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005654	nucleoplasm	Cellular Component	EXP (10548110\|11340163\|15029244)
GO:0005829	cytosol	Cellular Component	EXP (10793135\|11285280\|11535616\|11742988\|12070128)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA (9122200)
GO:0019787	small conjugating protein ligase activity	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0007049	cell cycle	Biological Process	NAS (15504738)
GO:0051436	negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (14593737\|15029244)
GO:0051301	cell division	Biological Process	IEA
GO:0051246	regulation of protein metabolic process	Biological Process	IEA
GO:0048015	phosphoinositide-mediated signaling	Biological Process	NAS (15504738)
GO:0043687	post-translational protein modification	Biological Process	IEA
GO:0031536	positive regulation of exit from mitosis	Biological Process	IMP (9122200)
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	EXP (11285280)
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA (9122200)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0016567	protein ubiquitination	Biological Process	IDA (9122200)
GO:0008054	cyclin catabolic process	Biological Process	IDA (9122200)
GO:0007067	mitosis	Biological Process	IEA
GO:0007051	spindle organization and biogenesis	Biological Process	NAS (15504738)
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	Biological Process	EXP (10793135)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000175063

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: