ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

110834

Symbol:

Chrna3

Full Name:

cholinergic receptor, nicotinic, alpha polypeptide 3

Alias:

(a)3|A730007P14Rik|Acra-3|Acra3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 B

Physical Location:

54859149-54874365 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1136 Symbol (Name): CHRNA3 (cholinergic receptor, nicotinic, alpha 3)

Ortholog Status:

The human GeneID 1136 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap5q	Alcohol Preference Drinking	9	25	10-35 (cM)	4.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_145129.2	NP_660111.2	NC_000075.5 range: 54859149..54874365, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	RCA (12466851)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0030054	cell junction	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0045211	postsynaptic membrane	Cellular Component	IC (11923417)
GO:0005892	nicotinic acetylcholine-gated receptor-channel complex	Cellular Component	IPI (17434683)
GO:0004872	receptor activity	Molecular Function	RCA (12466851)
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	Molecular Function	IMP (11923417)
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	RCA (12466851)
GO:0005216	ion channel activity	Molecular Function	RCA (12466851)
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	Molecular Function	RCA (12466851)
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0035095	behavioral response to nicotine	Biological Process	IMP (15275829)
GO:0042391	regulation of membrane potential	Biological Process	IMP (10318955)
GO:0048814	regulation of dendrite morphogenesis	Biological Process	IMP (11027228)
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process	IMP (16162937)
GO:0014056	regulation of acetylcholine secretion	Biological Process	IMP (16162937)
GO:0006810	transport	Biological Process	RCA (12466851)
GO:0006811	ion transport	Biological Process	RCA (12466851)
GO:0006937	regulation of muscle contraction	Biological Process	IMP (10318955)
GO:0006940	regulation of smooth muscle contraction	Biological Process	IMP (10318955\|10771006)
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	Biological Process	IMP (16162937)
GO:0007268	synaptic transmission	Biological Process	RCA (12466851)
GO:0007271	synaptic transmission, cholinergic	Biological Process	IMP (16162937)
GO:0007626	locomotory behavior	Biological Process	IMP (15275829)
GO:0060084	synaptic transmission involved in micturition	Biological Process	IMP (10771006)