ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CHEK2

Full Name:

CHK2 checkpoint homolog (S. pombe)

Alias:

CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53

Organism:

Homo sapiens (Human)

Chromosome:

22

Genetic Location:

22q11|22q12.1

Physical Location:

27413730-27467821 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CHEK2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001005735.1	NP_001005735.1	NC_000022.9 range: 27413730..27467821, complement
NM_007194.3	NP_009125.1	NC_000022.9 range: 27413730..27467821, complement
NM_145862.2	NP_665861.1	NC_000022.9 range: 27413730..27467821, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016605	PML body	Cellular Component	IDA (12402044)
GO:0005634	nucleus	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12402044)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (9836640)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	Biological Process	IDA (12402044)
GO:0000077	DNA damage checkpoint	Biological Process	TAS (9889122\|10617473)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000183765

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: