Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:112399
Full Name:egl nine homolog 3 (C. elegans)
Organism:Homo sapiens (Human)
Genetic Location:14q13.1
Physical Location:33463171-33490034 on NC_000014.7, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D14S70  33528945
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022073.3NP_071356.1NC_000014.7 range: 33463171..33490034, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0031418L-ascorbic acid bindingMolecular FunctionIEA
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsMolecular FunctionIEA
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15721254)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006915apoptosisBiological ProcessIEA
GO:0019538protein metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:112399
HuGE Navigator:112399