| Gene Information |
| Gene ID: | | 1124 |
| Symbol: | | CHN2 |
| Full Name: | | chimerin (chimaerin) 2 |
| Alias: | | ARHGAP3|BCH|MGC138360|RHOGAP3 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 7 |
| Genetic Location: | | 7p15.3 |
| Physical Location: | | 29200645-29520468 on NC_000007.12 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
| | Gene Information | | Original ID1: | | BG563170 | | Fold Change: | | 0.61 | | P Value: | | 0.02 | | Tissue: | | Nucleus accumbens |
| | Dataset Information | | Name: | | 15816859 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex and nucleus accumbens | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed | | Summary: | | Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005622 | intracellular | Cellular Component | IEA | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0005070 | SH3/SH2 adaptor activity | Molecular Function | TAS (8175705) | |
| GO:0005096 | GTPase activator activity | Molecular Function | TAS (7614486) | |
| GO:0005515 | protein binding | Molecular Function | IEA | |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | |
| GO:0019992 | diacylglycerol binding | Molecular Function | IEA | |
| GO:0046872 | metal ion binding | Molecular Function | IEA | |
| GO:0007242 | intracellular signaling cascade | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 1124 |
| HGNC: | | 1944 |
| Ensembl: | | ENSG00000106069 |
| MIM: | | 602857 |
| HPRD: | | 04173 |
| HuGE Navigator: | | 1124 |
| dbSNP: | | CHN2 |
| GeneCard: | | CHN2 |
| AceView: | | CHN2 |
