ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

USP18

Full Name:

ubiquitin specific peptidase 18

Alias:

ISG43|UBP43

Organism:

Homo sapiens (Human)

Chromosome:

22

Genetic Location:

22q11.21

Physical Location:

17012757-17040163 on NC_000022.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D22S420

2.04

0.0011

16239281

D22S1638

2.05

0.0011

17375064

Region:		16239281-17375064
Phenotype:		TOLMX (tolerance/maximum drinking)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017414.3	NP_059110.2	NC_000022.9 range: 17012757..17040163

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (10777664)
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000184979

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: