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Gene Information
Gene ID:114108
Full Name:PDZ and LIM domain 3
Organism:Rattus norvegicus (Rat)
Genetic Location:16q11
Physical Location:49637067-49668801 on NC_005115.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 27295    Symbol (Name): PDLIM3 (PDZ and LIM domain 3)
Ortholog Status:The human GeneID 27295 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pdlim3
Fold Change:1.28
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_053650.1NP_446102.1NC_005115.2 range: 49637067..49668801, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0015629actin cytoskeletonCellular ComponentISS
GO:0008092cytoskeletal protein bindingMolecular FunctionISS
GO:0008307structural constituent of muscleMolecular FunctionISS
GO:0042805actinin bindingMolecular FunctionIDA (9334352)
GO:0007015actin filament organizationBiological ProcessISS
GO:0007507heart developmentBiological ProcessISS
GO:0007519skeletal muscle developmentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:114108