ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdlim3

Full Name:

PDZ and LIM domain 3

Alias:

Actn2lp|Alp

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

16q11

Physical Location:

49637067-49668801 on NC_005115.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 27295 Symbol (Name): PDLIM3 (PDZ and LIM domain 3)

Ortholog Status:

The human GeneID 27295 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_053650.1	NP_446102.1	NC_005115.2 range: 49637067..49668801, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0015629	actin cytoskeleton	Cellular Component	ISS
GO:0008092	cytoskeletal protein binding	Molecular Function	ISS
GO:0008307	structural constituent of muscle	Molecular Function	ISS
GO:0042805	actinin binding	Molecular Function	IDA (9334352)
GO:0007015	actin filament organization	Biological Process	ISS
GO:0007507	heart development	Biological Process	ISS
GO:0007519	skeletal muscle development	Biological Process	ISS