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Gene Information
Gene ID:1143
Symbol:CHRNB4
Full Name:cholinergic receptor, nicotinic, beta 4
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q24
Physical Location:76703690-76720641 on NC_000015.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CHRNB4
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
CHRNB41Alcoholism
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000750.2NP_000741.1NC_000015.8 range: 76703690..76720641, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005892nicotinic acetylcholine-gated receptor-channel complexCellular ComponentTAS (11742001)
GO:0030054cell junctionCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005892nicotinic acetylcholine-gated receptor-channel complexCellular ComponentIDA (8906617)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0004889nicotinic acetylcholine-activated cation-selective channel activityMolecular FunctionTAS (8906617|11742001)
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0015464acetylcholine receptor activityMolecular FunctionIDA (8906617)
GO:0007271synaptic transmission, cholinergicBiological ProcessTAS (1330682)
GO:0007165signal transductionBiological ProcessIDA (8906617)
GO:0006811ion transportBiological ProcessTAS (8906617)
GO:0046928regulation of neurotransmitter secretionBiological ProcessNAS (11742001)
Other Database Cross Links
NCBI Entrez Gene:1143
HGNC:1964
Ensembl:ENSG00000117971
MIM:118509
HPRD:00337
HuGE Navigator:1143
dbSNP:CHRNB4
GeneCard:CHRNB4
AceView:CHRNB4