ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Chrnb1

Full Name:

cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)

Alias:

Achr-2|Acrb

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B3|11 40.0 cM

Physical Location:

69597538-69609444 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1140 Symbol (Name): CHRNB1 (cholinergic receptor, nicotinic, beta 1 (muscle))

Ortholog Status:

The human GeneID 1140 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009601.4	NP_033731.3	NC_000077.5 range: 69597538..69609444, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005886	plasma membrane	Cellular Component	IDA (12388596)
GO:0005892	nicotinic acetylcholine-gated receptor-channel complex	Cellular Component	IDA (8798466)
GO:0030594	neurotransmitter receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (8798466)
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	Molecular Function	IGI (2383398)
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	Molecular Function	IGI (8798466)
GO:0006811	ion transport	Biological Process	IEA
GO:0042391	regulation of membrane potential	Biological Process	IGI (2383398\|8798466)
GO:0006810	transport	Biological Process	IEA