| Gene Information |
| Gene ID: | | 114507 |
| Symbol: | | Slc5a3 |
| Full Name: | | solute carrier family 5 (inositol transporters), member 3 |
| Alias: | | Smit |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 11 |
| Genetic Location: | | 11q11 |
| Physical Location: | | 32063274-32065720 on NC_005110.2 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 6526 Symbol (Name): SLC5A3 (solute carrier family 5 (inositol transporters), member 3) |
| Ortholog Status: | | The human GeneID 6526 is not in current human dataset. |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Slc5a3 | | Fold Change: | | -1.4 | | Tissue: | | Accumbens |
| | Gene Information | | Original ID1: | | Slc5a3 | | Fold Change: | | -1.77 | | Tissue: | | Amygdala |
| | Gene Information | | Original ID1: | | Slc5a3 | | Fold Change: | | -1.44 | | Tissue: | | Frontalcortex |
| | Gene Information | | Original ID1: | | Slc5a3 | | Fold Change: | | -1.47 | | Tissue: | | Hippocampus |
| | Gene Information | | Original ID1: | | Slc5a3 | | Fold Change: | | -1.41 | | Tissue: | | Caudate-putamen |
| | Dataset Information | | Name: | | 17517326 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus | | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | | Publication: | | Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed | | Summary: | | The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change. |
|
|
| Gene Refseq Sequence Annotation |
|
| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0005215 | transporter activity | Molecular Function | IEA | |
| GO:0006811 | ion transport | Biological Process | IEA | |
| GO:0006814 | sodium ion transport | Biological Process | IEA | |
| GO:0007422 | peripheral nervous system development | Biological Process | ISS | |
| GO:0015798 | myo-inositol transport | Biological Process | ISS | |
| GO:0043576 | regulation of respiratory gaseous exchange | Biological Process | ISS | |
|
| Other Database Cross Links |
| NCBI Entrez Gene: | | 114507 |
| RGD: | | 621530 |
| Ensembl: | | ENSRNOG00000027076 |
| dbSNP: | | Slc5a3 |
