ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

11480

Symbol:

Acvr2a

Full Name:

activin receptor IIA

Alias:

ActRIIa|Acvr2|tActRII

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 C1.1|2 30.0 cM

Physical Location:

48669676-48757682 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 92 Symbol (Name): ACVR2A (activin A receptor, type IIA)

Ortholog Status:

The human GeneID 92 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcp1	Alcohol Preference Drinking	2	28	19-35 (cM)	5.3		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007396.4	NP_031422.3	NC_000068.6 range: 48669676..48757682

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0019838	growth factor binding	Molecular Function	IMP (12414726)
GO:0019838	growth factor binding	Molecular Function	IPI (11459935)
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0043621	protein self-association	Molecular Function	IPI (8612709)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0048185	activin binding	Molecular Function	IPI (1646080)
GO:0048186	inhibin beta-A binding	Molecular Function	IDA (7890768)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004675	transmembrane receptor protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004702	receptor signaling protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005024	transforming growth factor beta receptor activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0001934	positive regulation of protein amino acid phosphorylation	Biological Process	ISS (17472960)
GO:0001702	gastrulation with mouth forming second	Biological Process	IGI (10452853)
GO:0048706	embryonic skeletal development	Biological Process	IMP (7885474)
GO:0050999	regulation of nitric-oxide synthase activity	Biological Process	IMP (16093358)
GO:0043084	penile erection	Biological Process	IMP (16093358)
GO:0042713	sperm ejaculation	Biological Process	IMP (16093358)
GO:0030510	regulation of BMP signaling pathway	Biological Process	IMP (17472960)
GO:0030509	BMP signaling pathway	Biological Process	ISS (17472960)
GO:0007283	spermatogenesis	Biological Process	IGI (11459797)
GO:0007368	determination of left/right symmetry	Biological Process	IGI (16991118)
GO:0007498	mesoderm development	Biological Process	IMP (10452853)
GO:0008584	male gonad development	Biological Process	IMP (7885474)
GO:0009952	anterior/posterior pattern formation	Biological Process	IGI (10452853\|16991118)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	Biological Process	IEA
GO:0030509	BMP signaling pathway	Biological Process	IMP (17472960)
GO:0060011	Sertoli cell proliferation	Biological Process	IMP (11416011)