ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Shc3

Full Name:

src homology 2 domain-containing transforming protein C3

Alias:

ShcC

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

17p14

Physical Location:

19519981-19649460 on NC_005116.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 53358 Symbol (Name): SHC3 (SHC (Src homology 2 domain containing) transforming protein 3)

Ortholog Status:

The human GeneID 53358 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Gene Information

Dataset Information

Name:		17517326
Method:		Microarray
Tissue:		Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:		The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_341498.3	XP_341499.2	NC_005116.2 range: 19519981..19649460

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0001784	phosphotyrosine binding	Molecular Function	TAS (12882334)
GO:0005102	receptor binding	Molecular Function	TAS (12882334)
GO:0005515	protein binding	Molecular Function	ISS
GO:0007242	intracellular signaling cascade	Biological Process	TAS (12882334)
GO:0007611	learning and/or memory	Biological Process	ISS
GO:0035249	synaptic transmission, glutamatergic	Biological Process	ISS