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Gene Information
Gene ID:114858
Full Name:src homology 2 domain-containing transforming protein C3
Organism:Rattus norvegicus (Rat)
Genetic Location:17p14
Physical Location:19519981-19649460 on NC_005116.2
Gene Type:protein-coding
Human Ortholog:GeneID: 53358    Symbol (Name): SHC3 (SHC (Src homology 2 domain containing) transforming protein 3)
Ortholog Status:The human GeneID 53358 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Shc3
Fold Change:-1.29
Gene Information
Original ID1:Shc3
Fold Change:-1.39
Dataset Information
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_341498.3XP_341499.2NC_005116.2 range: 19519981..19649460
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001784phosphotyrosine bindingMolecular FunctionTAS (12882334)
GO:0005102receptor bindingMolecular FunctionTAS (12882334)
GO:0005515protein bindingMolecular FunctionISS
GO:0007242intracellular signaling cascadeBiological ProcessTAS (12882334)
GO:0007611learning and/or memoryBiological ProcessISS
GO:0035249synaptic transmission, glutamatergicBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:114858