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Gene Information
Gene ID:11502
Symbol:Adam9
Full Name:a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Alias:AU020942|MDC9|Mltng|mKIAA0021
Organism:Mus musculus (Mouse)
Chromosome:8
Genetic Location:8 A2|8 8.0 cM
Physical Location:26060096-26127265 on NC_000074.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8754    Symbol (Name): ADAM9 (ADAM metallopeptidase domain 9 (meltrin gamma))
Ortholog Status:The human GeneID 8754 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Adam9
Fold Change:2.01
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007404.2NP_031430.2NC_000074.5 range: 26060096..26127265, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (15739225)
GO:0005886plasma membraneCellular ComponentIDA (15739225)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0004222metalloendopeptidase activityMolecular FunctionRCA (16141072)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0008237metallopeptidase activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (10531379)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0007229integrin-mediated signaling pathwayBiological ProcessIEA
GO:0006508proteolysisBiological ProcessRCA (16141072)
Other Database Cross Links
NCBI Entrez Gene:11502
MGI:
Ensembl:ENSMUSG00000031555
dbSNP:Adam9
AceView:Adam9