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Gene Information
Gene ID:115265
Symbol:DDIT4L
Full Name:DNA-damage-inducible transcript 4-like
Alias:REDD2|Rtp801L
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q23
Physical Location:101326049-101330635 on NC_000004.10, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 140582 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D4S4232.610.000392691777
D4S4273.530.00003121646580
Region:92691777-121646580
Phenotype:ADSX (number of DSM-IV AD symptoms)
Name:16534506
Method:Linkage
Publication:Prescott et al. Mol Psychiatry. (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. PubMed
Summary:We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). A 4 cM genome scan was conducted using 474 families of which most (96%) were comprised by affected sib pairs. Nonparametric and quantitative linkage analyses were conducted using DSM-IV alcohol dependence (AD) and number of DSM-IV AD symptoms (ADSX). Quantitative results indicate strong linkage for number of AD criteria to a broad region of chromosome 4, ranging from 4q22 to 4q32 (peak multipoint LOD=4.59, P=2.1 x 10(-6), at D4S1611). We got the gene list in the region between two markers D4S423 and D4S427 as markers between (included) these two markers have LOD scores >2 with P value <0.0003.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_145244.2NP_660287.1NC_000004.10 range: 101326049..101330635, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentISS
GO:0009968negative regulation of signal transductionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:115265
HGNC:30555
Ensembl:ENSG00000145358
MIM:607730
HPRD:09663
HuGE Navigator:115265
dbSNP:DDIT4L
GeneCard:DDIT4L
AceView:DDIT4L