ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Adra1d

Full Name:

adrenergic receptor, alpha 1d

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 F1|2 74.9 cM

Physical Location:

131371092-131388020 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 146 Symbol (Name): ADRA1D (adrenergic, alpha-1D-, receptor)

Ortholog Status:

The human GeneID 146 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Adra1d
Fold Change:		0.47
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013460.4	NP_038488.4	NC_000068.6 range: 131371092..131388020, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0004937	alpha1-adrenergic receptor activity	Molecular Function	IDA (12595294)
GO:0004935	adrenoceptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	Biological Process	IMP (12595294)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0001986	negative regulation of the force of heart contraction during baroreceptor response to increased systemic arterial blood pressure	Biological Process	IMP (12595294)