ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

11554

Symbol:

Adrb1

Full Name:

adrenergic receptor, beta 1

Alias:

Adrb-1|beta-AR

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

19 D2|19 51.0 cM

Physical Location:

56796861-56798261 on NC_000085.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 153 Symbol (Name): ADRB1 (adrenergic, beta-1-, receptor)

Ortholog Status:

The human GeneID 153 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Calw2/Alcdp2	Chronic Alcohol Withdrawal	19	47	36.5-ter (cM)	5.3	6.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007419.2	NP_031445.2	NC_000085.5 range: 56796861..56798261

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	IMP (8693001)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0004940	beta1-adrenergic receptor activity	Molecular Function	IMP (8693001)
GO:0004940	beta1-adrenergic receptor activity	Molecular Function	IDA (7738011\|9305915)
GO:0004935	adrenoceptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0042596	fear response	Biological Process	IMP (15066288)
GO:0040015	negative regulation of multicellular organism growth	Biological Process	IGI (12387862)
GO:0031649	heat generation	Biological Process	IGI (12161655)
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Biological Process	IMP (8693001\|10358009)
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Biological Process	IDA (7761854)
GO:0009409	response to cold	Biological Process	IGI (12161655\|12387862)
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	Biological Process	IMP (8693001)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Biological Process	IMP (8693001)
GO:0002024	diet induced thermogenesis	Biological Process	IGI (12161655)
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	Biological Process	IGI (10358009\|11641423)
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	Biological Process	IMP (10358009\|11641423)
GO:0050873	brown fat cell differentiation	Biological Process	IGI (12387862)