ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Alox12

Full Name:

arachidonate 12-lipoxygenase

Alias:

9930022G08Rik|Alox12p|P-12LO

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 B3|11 40.0 cM

Physical Location:

70054956-70068842 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 239 Symbol (Name): ALOX12 (arachidonate 12-lipoxygenase)

Ortholog Status:

The human GeneID 239 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore4	Alcohol-induced Loss of Righting Reflex	11		36-42 (cM)	6.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007440.4	NP_031466.2	NC_000077.5 range: 70054956..70068842, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004052	arachidonate 12-lipoxygenase activity	Molecular Function	IEA
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016165	lipoxygenase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0006916	anti-apoptosis	Biological Process	IMP (15161019)
GO:0006691	leukotriene metabolic process	Biological Process	IEA
GO:0019370	leukotriene biosynthetic process	Biological Process	IEA
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP (15161019)