ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Aplp1

Full Name:

amyloid beta (A4) precursor-like protein 1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 B1|7 8.0 cM

Physical Location:

31220000-31230579 on NC_000073.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 333 Symbol (Name): APLP1 (amyloid beta (A4) precursor-like protein 1)

Ortholog Status:

The human GeneID 333 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Aplp1

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007467.2	NP_031493.2	NC_000073.5 range: 31220000..31230579, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (16141072)
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	IDA (16314516)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005905	coated pit	Cellular Component	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008201	heparin binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16314516)
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0030900	forebrain development	Biological Process	IGI (15385965)
GO:0030198	extracellular matrix organization and biogenesis	Biological Process	IGI (15385965)
GO:0006897	endocytosis	Biological Process	IEA
GO:0006378	mRNA polyadenylation	Biological Process	IDA (16314516)
GO:0008219	cell death	Biological Process	IEA
GO:0006417	regulation of translation	Biological Process	IDA (16314516)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEA