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Gene Information
Gene ID:11804
Symbol:Aplp2
Full Name:amyloid beta (A4) precursor-like protein 2
Alias:AI790698
Organism:Mus musculus (Mouse)
Chromosome:9
Genetic Location:9 A2-B|9 13.0 cM
Physical Location:30957141-31019399 on NC_000075.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 334    Symbol (Name): APLP2 (amyloid beta (A4) precursor-like protein 2)
Ortholog Status:The human GeneID 334 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Aplp2
Fold Change:2.26
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Ap5qAlcohol Preference Drinking92510-35 (cM)4.8 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009691.2NP_033821.1NC_000075.5 range: 30957141..31019399, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0005634nucleusCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0005515protein bindingMolecular FunctionIPI (8894693|16314516)
GO:0005488bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0030901midbrain developmentBiological ProcessIGI (15689559)
GO:0030900forebrain developmentBiological ProcessIGI (15385965|15689559)
GO:0030198extracellular matrix organization and biogenesisBiological ProcessIGI (15385965)
GO:0001967suckling behaviorBiological ProcessIGI (9461064)
GO:0009790embryonic developmentBiological ProcessIGI (15689559)
GO:0007626locomotory behaviorBiological ProcessIGI (9461064)
GO:0007617mating behaviorBiological ProcessIGI (9461064)
GO:0007176regulation of epidermal growth factor receptor activityBiological ProcessIGI (17556541)
GO:0006878cellular copper ion homeostasisBiological ProcessIMP (10526140)
GO:0050885neuromuscular process controlling balanceBiological ProcessIGI (9461064)
Other Database Cross Links
NCBI Entrez Gene:11804
MGI:
Ensembl:ENSMUSG00000031996
dbSNP:Aplp2
AceView:Aplp2