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Gene Information
Gene ID:11841
Symbol:Arf2
Full Name:ADP-ribosylation factor 2
Organism:Mus musculus (Mouse)
Chromosome:11
Genetic Location:11 E1|11 62.0 cM
Physical Location:103828184-103846649 on NC_000077.5
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Arf2
Fold Change:1.94
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007477.4NP_031503.1NC_000077.5 range: 103828184..103846649
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005794Golgi apparatusCellular ComponentRCA (12466851)
GO:0005794Golgi apparatusCellular ComponentIDA (8947846)
GO:0005622intracellularCellular ComponentIEA
GO:0008565protein transporter activityMolecular FunctionRCA (12466851)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionTAS (8947846)
GO:0005525GTP bindingMolecular FunctionRCA (12466851)
GO:0005515protein bindingMolecular FunctionIPI (12679809)
GO:0005215transporter activityMolecular FunctionRCA (12466851)
GO:0015031protein transportBiological ProcessTAS (8947846)
GO:0015031protein transportBiological ProcessRCA (12466851)
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0006886intracellular protein transportBiological ProcessRCA (12466851)
GO:0006810transportBiological ProcessIEA
GO:0016192vesicle-mediated transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:11841
MGI:
Ensembl:ENSMUSG00000062421
dbSNP:Arf2
AceView:Arf2