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Gene Information
Gene ID:11852
Full Name:ras homolog gene family, member B
Organism:Mus musculus (Mouse)
Genetic Location:12 A1.1
Physical Location:8504563-8506790 on NC_000078.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 388    Symbol (Name): RHOB (ras homolog gene family, member B)
Ortholog Status:The human GeneID 388 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Arhb
Fold Change:1.65
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007483.2NP_031509.1NC_000078.5 range: 8504563..8506790, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005768endosomeCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIDA (15093731)
GO:0005634nucleusCellular ComponentIDA (14597666)
GO:0005622intracellularCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionTAS (1400319)
GO:0005515protein bindingMolecular FunctionIPI (8543060)
GO:0003924GTPase activityMolecular FunctionRCA (16141072)
GO:0030154cell differentiationBiological ProcessIEA
GO:0045766positive regulation of angiogenesisBiological ProcessIMP (14597666)
GO:0015031protein transportBiological ProcessIEA
GO:0009987cellular processBiological ProcessRCA (16141072)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007266Rho protein signal transductionBiological ProcessRCA (16141072)
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessIDA (11564874)
GO:0007049cell cycleBiological ProcessIEA
GO:0006927transformed cell apoptosisBiological ProcessIDA (11353846)
GO:0006915apoptosisBiological ProcessIEA
GO:0006810transportBiological ProcessIEA
GO:0001525angiogenesisBiological ProcessIEA
GO:0045786negative regulation of cell cycleBiological ProcessIMP (11564874)
Other Database Cross Links
NCBI Entrez Gene:11852