ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rhob

Full Name:

ras homolog gene family, member B

Alias:

AA017882|Arh6|Arhb|MGC117867

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

12 A1.1

Physical Location:

8504563-8506790 on NC_000078.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 388 Symbol (Name): RHOB (ras homolog gene family, member B)

Ortholog Status:

The human GeneID 388 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Arhb
Fold Change:		1.65
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007483.2	NP_031509.1	NC_000078.5 range: 8504563..8506790, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005768	endosome	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IDA (15093731)
GO:0005634	nucleus	Cellular Component	IDA (14597666)
GO:0005622	intracellular	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	TAS (1400319)
GO:0005515	protein binding	Molecular Function	IPI (8543060)
GO:0003924	GTPase activity	Molecular Function	RCA (16141072)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0045766	positive regulation of angiogenesis	Biological Process	IMP (14597666)
GO:0015031	protein transport	Biological Process	IEA
GO:0009987	cellular process	Biological Process	RCA (16141072)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007266	Rho protein signal transduction	Biological Process	RCA (16141072)
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IDA (11564874)
GO:0007049	cell cycle	Biological Process	IEA
GO:0006927	transformed cell apoptosis	Biological Process	IDA (11353846)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0001525	angiogenesis	Biological Process	IEA
GO:0045786	negative regulation of cell cycle	Biological Process	IMP (11564874)