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Gene Information
Gene ID:1191
Symbol:CLU
Full Name:clusterin
Alias:AAG4|APOJ|CLI|KUB1|MGC24903|SGP-2|SGP2|SP-40|TRPM-2|TRPM2
Organism:Homo sapiens (Human)
Chromosome:8
Genetic Location:8p21-p12
Physical Location:27510367-27528243 on NC_000008.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 12759 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M63379
Fold Change:-1.7, -1.5
Note:Differential expression on the oligonucleotide array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:CLU
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001831.2NP_001822.2NC_000008.9 range: 27510367..27528243, complement
NM_203339.1NP_976084.1NC_000008.9 range: 27510367..27528243, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentNAS (14718574)
GO:0005515protein bindingMolecular FunctionIPI (17043677)
GO:0006629lipid metabolic processBiological ProcessNAS (2387851)
GO:0006915apoptosisBiological ProcessIEA
GO:0006958complement activation, classical pathwayBiological ProcessIEA
GO:0008219cell deathBiological ProcessIEA
GO:0045087innate immune responseBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:1191
HGNC:2095
Ensembl:ENSG00000120885
MIM:185430
HPRD:01706
HuGE Navigator:1191
dbSNP:CLU
GeneCard:CLU
AceView:CLU