ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CLU

Full Name:

clusterin

Alias:

AAG4|APOJ|CLI|KUB1|MGC24903|SGP-2|SGP2|SP-40|TRPM-2|TRPM2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8p21-p12

Physical Location:

27510367-27528243 on NC_000008.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12759 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M63379
Fold Change:		-1.7, -1.5
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Information

Original ID1:

CLU

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	NAS (14718574)
GO:0005515	protein binding	Molecular Function	IPI (17043677)
GO:0006629	lipid metabolic process	Biological Process	NAS (2387851)
GO:0006915	apoptosis	Biological Process	IEA
GO:0006958	complement activation, classical pathway	Biological Process	IEA
GO:0008219	cell death	Biological Process	IEA
GO:0045087	innate immune response	Biological Process	IEA