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Gene Information
Gene ID:11941
Symbol:Atp2b2
Full Name:ATPase, Ca++ transporting, plasma membrane 2
Alias:D6Abb2e|PMCA2|dfw|jog|wms|wri
Organism:Mus musculus (Mouse)
Chromosome:6
Genetic Location:6 E3|6 49.5 cM
Physical Location:113695661-113992019 on NC_000072.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 491    Symbol (Name): ATP2B2 (ATPase, Ca++ transporting, plasma membrane 2)
Ortholog Status:The human GeneID 491 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Atp2b2
Fold Change:2.16
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001036684.1NP_001031761.1NC_000072.5 range: 113695661..113992019, complement
NM_009723.2NP_033853.1NC_000072.5 range: 113695661..113992019, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043025cell somaCellular ComponentIDA (10441500)
GO:0005783endoplasmic reticulumCellular ComponentIDA (17234811)
GO:0005886plasma membraneCellular ComponentIDA (17234811)
GO:0005929ciliumCellular ComponentIDA (10441500)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0016324apical plasma membraneCellular ComponentIDA (17823248)
GO:0005792microsomeCellular ComponentIDA (15302868)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanismMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0015085calcium ion transmembrane transporter activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substancesMolecular FunctionIEA
GO:0030899calcium-dependent ATPase activityMolecular FunctionIMP (17823248)
GO:0005516calmodulin bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005388calcium-transporting ATPase activityMolecular FunctionIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0060113inner ear receptor cell differentiationBiological ProcessIMP (11875276)
GO:0042428serotonin metabolic processBiological ProcessIMP (2765934)
GO:0040011locomotionBiological ProcessIMP (16880690)
GO:0042472inner ear morphogenesisBiological ProcessIMP (9668038)
GO:0050885neuromuscular process controlling balanceBiological ProcessIMP (9668038|15350283|16845470)
GO:0045299otolith mineralizationBiological ProcessIMP (9668038)
GO:0046068cGMP metabolic processBiological ProcessIMP (3038581|7518067)
GO:0060088auditory receptor cell stereocilium organization and biogenesisBiological ProcessIMP (11875276)
GO:0051928positive regulation of calcium ion transportBiological ProcessIMP (17823248)
GO:0048167regulation of synaptic plasticityBiological ProcessIMP (17409239)
GO:0050910detection of mechanical stimulus involved in sensory perception of soundBiological ProcessIMP (16529873)
GO:0050808synapse organization and biogenesisBiological ProcessIMP (7683393)
GO:0048839inner ear developmentBiological ProcessIMP (11875276)
GO:0021707cerebellar granule cell differentiationBiological ProcessIMP (9668038)
GO:0021702cerebellar Purkinje cell differentiationBiological ProcessIMP (9668038)
GO:0006810transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006812cation transportBiological ProcessIEA
GO:0006816calcium ion transportBiological ProcessIMP (15302868|17234811)
GO:0006874cellular calcium ion homeostasisBiological ProcessIMP (11985881|17234811)
GO:0006996organelle organization and biogenesisBiological ProcessIMP (11875276)
GO:0007595lactationBiological ProcessIMP (15302868)
GO:0007605sensory perception of soundBiological ProcessIMP (9325047|9668038|9697703|10687933|11950541|15350283|16845470|17234811)
GO:0007626locomotory behaviorBiological ProcessIMP (2765934|3038581|7518067|9668038|16845470)
GO:0008152metabolic processBiological ProcessIEA
GO:0008361regulation of cell sizeBiological ProcessIMP (11875276)
GO:0007605sensory perception of soundBiological ProcessIGI (9325047)
GO:0021549cerebellum developmentBiological ProcessIMP (16880690)
GO:0021692cerebellar Purkinje cell layer morphogenesisBiological ProcessIMP (17409239)
GO:0000902cell morphogenesisBiological ProcessIMP (10441500)
Other Database Cross Links
NCBI Entrez Gene:11941
MGI:
Ensembl:ENSMUSG00000030302
dbSNP:Atp2b2
AceView:Atp2b2