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Gene Information
Gene ID:1196
Symbol:CLK2
Full Name:CDC-like kinase 2
Alias:MGC61500|hCLK2
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1q21
Physical Location:153499282-153509904 on NC_000001.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF023268
Fold Change:-1.5, -1.5
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003993.2NP_003984.2NC_000001.9 range: 153499282..153509904, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionTAS (7990150)
GO:0004713protein-tyrosine kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:1196
HGNC:2069
Ensembl:ENSG00000176444
MIM:602989
HPRD:04289
HuGE Navigator:1196
dbSNP:CLK2
GeneCard:CLK2
AceView:CLK2