ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CLK2

Full Name:

CDC-like kinase 2

Alias:

MGC61500|hCLK2

Organism:

Homo sapiens (Human)

Chromosome:

1

Genetic Location:

1q21

Physical Location:

153499282-153509904 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF023268
Fold Change:		-1.5, -1.5
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003993.2	NP_003984.2	NC_000001.9 range: 153499282..153509904, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (7990150)
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000176444

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: