ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

C1qb

Full Name:

complement component 1, q subcomponent, beta polypeptide

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D3|4 66.1 cM

Physical Location:

136436059-136442091 on NC_000070.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 713 Symbol (Name): C1QB (complement component 1, q subcomponent, B chain)

Ortholog Status:

The human GeneID 713 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

C1qb

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap3q	Alcohol Preference Drinking	4	75	65-ter (cM)	4.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009777.2	NP_033907.1	NC_000070.5 range: 136436059..136442091, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0006817	phosphate transport	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0006958	complement activation, classical pathway	Biological Process	IEA
GO:0045087	innate immune response	Biological Process	IEA