ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddr1

Full Name:

discoidin domain receptor family, member 1

Alias:

6030432F18|AI323681|CD167a|Cak|Nep|PTK3A

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 C|17 21.5 cM

Physical Location:

35818511-35841083 on NC_000083.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 780 Symbol (Name): DDR1 (discoidin domain receptor tyrosine kinase 1)

Ortholog Status:

The human GeneID 780 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ntrk4
Fold Change:		0.66
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0007155	cell adhesion	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA