ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CCR2

Full Name:

chemokine (C-C motif) receptor 2

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p21.31

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

CCR2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005625	soluble fraction	Cellular Component	TAS (8995400)
GO:0005737	cytoplasm	Cellular Component	IDA (15995708)
GO:0005886	plasma membrane	Cellular Component	IDA (15995708)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8146186)
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0016493	C-C chemokine receptor activity	Molecular Function	IEA
GO:0031727	CCR2 chemokine receptor binding	Molecular Function	IDA (15995708)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0006954	inflammatory response	Biological Process	TAS (10623817)
GO:0019221	cytokine and chemokine mediated signaling pathway	Biological Process	IDA (15995708)
GO:0007259	JAK-STAT cascade	Biological Process	TAS (9670957)
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS (9548499)
GO:0007194	negative regulation of adenylate cyclase activity	Biological Process	TAS (8995400)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0006935	chemotaxis	Biological Process	TAS (10623817)
GO:0006955	immune response	Biological Process	TAS (10751368)
GO:0006968	cellular defense response	Biological Process	TAS (10201901)