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Gene Information
Gene ID:1234
Symbol:CCR5
Full Name:chemokine (C-C motif) receptor 5
Alias:CC-CKR-5|CCCKR5|CD195|CKR-5|CKR5|CMKBR5
Organism:Homo sapiens (Human)
Chromosome:3
Genetic Location:3p21.31
Physical Location:46386636-46392700 on NC_000003.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CCR5
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
CCR51Alcohol-Induced Disorders
CCR51Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000579.3NP_000570.1NC_000003.10 range: 46386636..46392700
NM_001100168.1NP_001093638.1NC_000003.10 range: 46386636..46392700
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentTAS (10201901)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005768endosomeCellular ComponentTAS (10679098)
GO:0005737cytoplasmCellular ComponentTAS (10415069)
GO:0016021integral to membraneCellular ComponentIEA
GO:0009897external side of plasma membraneCellular ComponentIDA (11278962)
GO:0005887integral to plasma membraneCellular ComponentTAS (10393923)
GO:0016493C-C chemokine receptor activityMolecular FunctionIEA
GO:0015026coreceptor activityMolecular FunctionTAS (10469138)
GO:0016493C-C chemokine receptor activityMolecular FunctionNAS (8639485)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12421915|15001559)
GO:0004872receptor activityMolecular FunctionIEA
GO:0004435phosphoinositide phospholipase C activityMolecular FunctionTAS (8663314)
GO:0003779actin bindingMolecular FunctionIDA (12421915)
GO:0007267cell-cell signalingBiological ProcessTAS (10679098)
GO:0007204elevation of cytosolic calcium ion concentrationBiological ProcessTAS (10201901)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (10393923)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0006968cellular defense responseBiological ProcessTAS (10201901)
GO:0006955immune responseBiological ProcessTAS (8639485)
GO:0006954inflammatory responseBiological ProcessTAS (8639485)
GO:0006935chemotaxisBiological ProcessTAS (10741397)
GO:0019059initiation of viral infectionBiological ProcessEXP (12091904)
Other Database Cross Links
NCBI Entrez Gene:1234
HGNC:1606
Ensembl:ENSG00000160791
MIM:601373
HPRD:03223
HuGE Navigator:1234
dbSNP:CCR5
GeneCard:CCR5
AceView:CCR5