ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

12367

Symbol:

Casp3

Full Name:

caspase 3

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 B1.1|8 26.0 cM

Physical Location:

47702802-47724070 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 836 Symbol (Name): CASP3 (caspase 3, apoptosis-related cysteine peptidase)

Ortholog Status:

The human GeneID 836 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws3/Alcw6	Chronic Alcohol Withdrawal	8		16-43 (cM)	3.5	0.0003	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009810.2	NP_033940.1	NC_000074.5 range: 47702802..47724070

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (12477715)
GO:0030693	caspase activity	Molecular Function	RCA (12819136)
GO:0030693	caspase activity	Molecular Function	IMP (16469926)
GO:0030693	caspase activity	Molecular Function	IDA (12427836\|13679151\|14561754\|14657025\|15456877\|16183742)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IDA (12954857)
GO:0008233	peptidase activity	Molecular Function	IMP (11549719\|12970760)
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0004861	cyclin-dependent protein kinase inhibitor activity	Molecular Function	IMP (12970760)
GO:0030693	caspase activity	Molecular Function	ISO
GO:0030216	keratinocyte differentiation	Biological Process	IMP (15068794)
GO:0009611	response to wounding	Biological Process	IDA (14507967)
GO:0001782	B cell homeostasis	Biological Process	IMP (12970760)
GO:0030889	negative regulation of B cell proliferation	Biological Process	IMP (12970760)
GO:0043029	T cell homeostasis	Biological Process	IMP (12970760)
GO:0043066	negative regulation of apoptosis	Biological Process	ISO
GO:0045165	cell fate commitment	Biological Process	IMP (15068794)
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IMP (12970760)
GO:0045786	negative regulation of cell cycle	Biological Process	IMP (12970760)
GO:0046007	negative regulation of activated T cell proliferation	Biological Process	IMP (12970760)
GO:0009411	response to UV	Biological Process	IGI (16469926)
GO:0009411	response to UV	Biological Process	IDA (11092819)
GO:0008631	induction of apoptosis by oxidative stress	Biological Process	IDA (12954857)
GO:0001836	release of cytochrome c from mitochondria	Biological Process	IGI (16469926)
GO:0006309	DNA fragmentation during apoptosis	Biological Process	IMP (16469926)
GO:0006508	proteolysis	Biological Process	RCA (12819136)
GO:0006915	apoptosis	Biological Process	IDA (16880525)
GO:0006915	apoptosis	Biological Process	IGI (10618441)
GO:0006915	apoptosis	Biological Process	IMP (10618441\|11549719)
GO:0006917	induction of apoptosis	Biological Process	IDA (12944902\|14645204\|15456877)
GO:0006917	induction of apoptosis	Biological Process	IGI (16469926)
GO:0006917	induction of apoptosis	Biological Process	IMP (9512515\|10479688)
GO:0006917	induction of apoptosis	Biological Process	RCA (12819136)
GO:0006974	response to DNA damage stimulus	Biological Process	IDA (11092819)
GO:0007507	heart development	Biological Process	IGI (16469926)
GO:0007605	sensory perception of sound	Biological Process	IMP (11374883)
GO:0008625	induction of apoptosis via death domain receptors	Biological Process	IMP (12970760)
GO:0051402	neuron apoptosis	Biological Process	IDA (12427836)