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Gene Information
Gene ID:12367
Symbol:Casp3
Full Name:caspase 3
Alias:A830040C14Rik|Apopain|CPP32|Caspase-3|Lice|Yama
Organism:Mus musculus (Mouse)
Chromosome:8
Genetic Location:8 B1.1|8 26.0 cM
Physical Location:47702802-47724070 on NC_000074.5
Gene Type:protein-coding
Human Ortholog:GeneID: 836    Symbol (Name): CASP3 (caspase 3, apoptosis-related cysteine peptidase)
Ortholog Status:The human GeneID 836 is not in current human dataset.
Gene in Ethanol Study Datasets
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Caws3/Alcw6Chronic Alcohol Withdrawal8 16-43 (cM)3.50.0003SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_009810.2NP_033940.1NC_000074.5 range: 47702802..47724070
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (12477715)
GO:0030693caspase activityMolecular FunctionRCA (12819136)
GO:0030693caspase activityMolecular FunctionIMP (16469926)
GO:0030693caspase activityMolecular FunctionIDA (12427836|13679151|14561754|14657025|15456877|16183742)
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIDA (12954857)
GO:0008233peptidase activityMolecular FunctionIMP (11549719|12970760)
GO:0008234cysteine-type peptidase activityMolecular FunctionIEA
GO:0004861cyclin-dependent protein kinase inhibitor activityMolecular FunctionIMP (12970760)
GO:0030693caspase activityMolecular FunctionISO
GO:0030216keratinocyte differentiationBiological ProcessIMP (15068794)
GO:0009611response to woundingBiological ProcessIDA (14507967)
GO:0001782B cell homeostasisBiological ProcessIMP (12970760)
GO:0030889negative regulation of B cell proliferationBiological ProcessIMP (12970760)
GO:0043029T cell homeostasisBiological ProcessIMP (12970760)
GO:0043066negative regulation of apoptosisBiological ProcessISO
GO:0045165cell fate commitmentBiological ProcessIMP (15068794)
GO:0045736negative regulation of cyclin-dependent protein kinase activityBiological ProcessIMP (12970760)
GO:0045786negative regulation of cell cycleBiological ProcessIMP (12970760)
GO:0046007negative regulation of activated T cell proliferationBiological ProcessIMP (12970760)
GO:0009411response to UVBiological ProcessIGI (16469926)
GO:0009411response to UVBiological ProcessIDA (11092819)
GO:0008631induction of apoptosis by oxidative stressBiological ProcessIDA (12954857)
GO:0001836release of cytochrome c from mitochondriaBiological ProcessIGI (16469926)
GO:0006309DNA fragmentation during apoptosisBiological ProcessIMP (16469926)
GO:0006508proteolysisBiological ProcessRCA (12819136)
GO:0006915apoptosisBiological ProcessIDA (16880525)
GO:0006915apoptosisBiological ProcessIGI (10618441)
GO:0006915apoptosisBiological ProcessIMP (10618441|11549719)
GO:0006917induction of apoptosisBiological ProcessIDA (12944902|14645204|15456877)
GO:0006917induction of apoptosisBiological ProcessIGI (16469926)
GO:0006917induction of apoptosisBiological ProcessIMP (9512515|10479688)
GO:0006917induction of apoptosisBiological ProcessRCA (12819136)
GO:0006974response to DNA damage stimulusBiological ProcessIDA (11092819)
GO:0007507heart developmentBiological ProcessIGI (16469926)
GO:0007605sensory perception of soundBiological ProcessIMP (11374883)
GO:0008625induction of apoptosis via death domain receptorsBiological ProcessIMP (12970760)
GO:0051402neuron apoptosisBiological ProcessIDA (12427836)
Other Database Cross Links
NCBI Entrez Gene:12367
MGI:
Ensembl:ENSMUSG00000031628
dbSNP:Casp3
AceView:Casp3