ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Casp8

Full Name:

caspase 8

Alias:

Caspase-8|FLICE|MACH|Mch5

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 B|1 30.1 cM

Physical Location:

58852217-58904346 on NC_000067.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 841 Symbol (Name): CASP8 (caspase 8, apoptosis-related cysteine peptidase)

Ortholog Status:

The human GeneID 841 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws1/Alcw5	Chronic Alcohol Withdrawal	1		28-47 (cM)	6.5	3.00E-07	Significant	PARC

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030690	Noc1p-Noc2p complex	Cellular Component	IMP (14657025)
GO:0005634	nucleus	Cellular Component	IDA (12065591)
GO:0005737	cytoplasm	Cellular Component	IDA (12065591)
GO:0008233	peptidase activity	Molecular Function	IMP (12404118)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16469705)
GO:0030693	caspase activity	Molecular Function	IDA (12065591\|15456877\|16183742)
GO:0030225	macrophage differentiation	Biological Process	IMP (15322156)
GO:0008632	apoptotic program	Biological Process	ISO
GO:0001525	angiogenesis	Biological Process	IMP (12404118)
GO:0007507	heart development	Biological Process	IMP (12404118)
GO:0006915	apoptosis	Biological Process	IMP (15322156)
GO:0006915	apoptosis	Biological Process	IDA (12065591\|16183742)
GO:0006508	proteolysis	Biological Process	IEA
GO:0001841	neural tube formation	Biological Process	IMP (12404118)
GO:0042981	regulation of apoptosis	Biological Process	IEA