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Gene Information
Gene ID:12461
Full Name:chaperonin subunit 2 (beta)
Organism:Mus musculus (Mouse)
Genetic Location:10 D2
Physical Location:116488053-116500869 on NC_000076.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10576    Symbol (Name): CCT2 (chaperonin containing TCP1, subunit 2 (beta))
Ortholog Status:The human GeneID 10576 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cct2
Fold Change:1.3
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007636.2NP_031662.2NC_000076.5 range: 116488053..116500869, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005832chaperonin-containing T-complexCellular ComponentIDA (7953530)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0051082unfolded protein bindingMolecular FunctionIEA
GO:0006457protein foldingBiological ProcessIEA
GO:0044267cellular protein metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:12461