ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

12501

Symbol:

Cd3e

Full Name:

CD3 antigen, epsilon polypeptide

Alias:

AI504783|CD3|CD3epsilon|T3e

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 A5.2|9 26.0 cM

Physical Location:

44806825-44817672 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 916 Symbol (Name): CD3E (CD3e molecule, epsilon (CD3-TCR complex))

Ortholog Status:

The human GeneID 916 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap5q	Alcohol Preference Drinking	9	25	10-35 (cM)	4.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007648.4	NP_031674.1	NC_000075.5 range: 44806825..44817672, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0001772	immunological synapse	Cellular Component	IDA (14635057\|15064761)
GO:0042105	alpha-beta T cell receptor complex	Cellular Component	IDA (9064344\|9208839)
GO:0042101	T cell receptor complex	Cellular Component	ISO
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	ISO
GO:0009897	external side of plasma membrane	Cellular Component	IDA (7630421\|8125140\|8666928\|10072077\|10485657\|15368291)
GO:0005886	plasma membrane	Cellular Component	ISO
GO:0004871	signal transducer activity	Molecular Function	IDA (7630421)
GO:0005515	protein binding	Molecular Function	IPI (8196616\|11390434)
GO:0004888	transmembrane receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0050850	positive regulation of calcium-mediated signaling	Biological Process	IDA (7630421\|8943715)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA (10485657)
GO:0046649	lymphocyte activation	Biological Process	IMP (15843560)
GO:0046641	positive regulation of alpha-beta T cell proliferation	Biological Process	IDA (8125140)
GO:0045879	negative regulation of smoothened signaling pathway	Biological Process	IDA (10981962)
GO:0045060	negative thymic T cell selection	Biological Process	IDA (7630421)
GO:0008624	induction of apoptosis by extracellular signals	Biological Process	IDA (8666928)
GO:0042102	positive regulation of T cell proliferation	Biological Process	IDA (10072077\|10485657\|15368291)
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IDA (7630421\|8943715)
GO:0050852	T cell receptor signaling pathway	Biological Process	IDA (10485657)