ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cdc25b

Full Name:

cell division cycle 25 homolog B (S. pombe)

Alias:

AI604853

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 F1|2 73.9 cM

Physical Location:

131012814-131024200 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 994 Symbol (Name): CDC25B (cell division cycle 25 homolog B (S. pombe))

Ortholog Status:

The human GeneID 994 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cdc25b
Fold Change:		0.72
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_023117.2	NP_075606.1	NC_000068.6 range: 131012814..131024200

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IEA
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000087	M phase of mitotic cell cycle	Biological Process	IEA
GO:0045860	positive regulation of protein kinase activity	Biological Process	IMP (11912493)
GO:0007144	female meiosis I	Biological Process	IMP (11912493)
GO:0007067	mitosis	Biological Process	IEA
GO:0007049	cell cycle	Biological Process	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IEA
GO:0001556	oocyte maturation	Biological Process	IMP (11912493)
GO:0051301	cell division	Biological Process	IEA