ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cdkn1a

Full Name:

cyclin-dependent kinase inhibitor 1A (P21)

Alias:

CAP20|CDKI|CIP1|Cdkn1|P21|SDI1|Waf1|mda6|p21Cip1|p21WAF

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 A3.3|17 15.23 cM

Physical Location:

29230719-29237666 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1026 Symbol (Name): CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1))

Ortholog Status:

The human GeneID 1026 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AW048937
Fold Change:		2.3, 2.6, 4.3, 4.9
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007669.4	NP_031695.1	NC_000083.5 range: 29230719..29237666

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	Cellular Component	IPI (12970760)
GO:0005634	nucleus	Cellular Component	IDA (12970760)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	IDA (15964824)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0030332	cyclin binding	Molecular Function	IPI (12124778)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0004861	cyclin-dependent protein kinase inhibitor activity	Molecular Function	IDA (12130539)
GO:0004860	protein kinase inhibitor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (12124778\|12588994\|12970760)
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IDA (12130539)
GO:0043071	positive regulation of non-apoptotic programmed cell death	Biological Process	IMP (12759355)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (12952892)
GO:0030890	positive regulation of B cell proliferation	Biological Process	IGI (12970760)
GO:0007049	cell cycle	Biological Process	IEA
GO:0009411	response to UV	Biological Process	IMP (12952892)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (12759355\|14712235)
GO:0006974	response to DNA damage stimulus	Biological Process	IMP (12952892)
GO:0007050	cell cycle arrest	Biological Process	IDA (15831459)
GO:0051726	regulation of cell cycle	Biological Process	IDA (12588994)