ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cldn5

Full Name:

claudin 5

Alias:

AI854493|MBEC1|MGC102088|Tmvcf

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

16 A3|16 11.65 cM

Physical Location:

18776939-18778352 on NC_000082.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7122 Symbol (Name): CLDN5 (claudin 5 (transmembrane protein deleted in velocardiofacial syndrome))

Ortholog Status:

The human GeneID 7122 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U82758
Fold Change:		-1.4, NC, -1.7, -1.5
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013805.3	NP_038833.2	NC_000082.5 range: 18776939..18778352

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005923	tight junction	Cellular Component	IDA (9892664)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	NAS (9892664)
GO:0030054	cell junction	Cellular Component	IEA
GO:0005198	structural molecule activity	Molecular Function	IEA
GO:0016337	cell-cell adhesion	Biological Process	IC (10508865)