| Gene Information |
| Gene ID: | | 1282 |
| Symbol: | | COL4A1 |
| Full Name: | | collagen, type IV, alpha 1 |
| Alias: | | arresten |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 13 |
| Genetic Location: | | 13q34 |
| Physical Location: | | 109599310-109757496 on NC_000013.9, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AA150402 | | Fold Change: | | 0.68 | | P Value: | | 0.02 | | Tissue: | | Nucleus accumbens |
| | Dataset Information | | Name: | | 15816859 | | Method: | | Microarray | | Tissue: | | Prefrontal cortex and nucleus accumbens | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed | | Summary: | | Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test. |
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| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D13S1265 | | | 108126458 | | Region: | | 106126458-110126458 | | Phenotype: | | Alcoholism phenotype along with age, gender, and P300 or constraint | | Name: | | 15211641 | | Method: | | Linkage | | Publication: | | Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed | | Summary: | | A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb). |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | NAS (14718574) | |
| GO:0005581 | collagen | Cellular Component | IEA | |
| GO:0005604 | basement membrane | Cellular Component | IEA | |
| GO:0005737 | cytoplasm | Cellular Component | IEA | |
| GO:0005201 | extracellular matrix structural constituent | Molecular Function | IEA | |
| GO:0005488 | binding | Molecular Function | IEA | |
| GO:0006817 | phosphate transport | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 1282 |
| HGNC: | | 2202 |
| Ensembl: | | ENSG00000187498 |
| MIM: | | 120130 |
| HPRD: | | 00359 |
| HuGE Navigator: | | 1282 |
| dbSNP: | | COL4A1 |
| GeneCard: | | COL4A1 |
| AceView: | | COL4A1 |
