ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Csk

Full Name:

c-src tyrosine kinase

Alias:

AW212630

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 B|9 32.0 cM

Physical Location:

57474452-57492986 on NC_000075.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1445 Symbol (Name): CSK (c-src tyrosine kinase)

Ortholog Status:

The human GeneID 1445 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap5q	Alcohol Preference Drinking	9	25	10-35 (cM)	4.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007783.2	NP_031809.2	NC_000075.5 range: 57474452..57492986, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005911	intercellular junction	Cellular Component	IDA (15861137)
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	TAS (12612075)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	TAS (12612075)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	TAS (12612075)
GO:0005515	protein binding	Molecular Function	IPI (12612075)
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004715	non-membrane spanning protein tyrosine kinase activity	Molecular Function	IEA
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (15861137)
GO:0008285	negative regulation of cell proliferation	Biological Process	IGI (15861137)
GO:0007242	intracellular signaling cascade	Biological Process	TAS (12612075)
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (12612075)
GO:0050863	regulation of T cell activation	Biological Process	TAS (12612075)