ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ctsb

Full Name:

cathepsin B

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 D1|14 28.0 cM

Physical Location:

63741301-63764757 on NC_000080.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1508 Symbol (Name): CTSB (cathepsin B)

Ortholog Status:

The human GeneID 1508 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Ctsb

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws5/Alcw7	Chronic Alcohol Withdrawal	14		24-48 (cM)	4.2	6.00E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_007798.2	NP_031824.1	NC_000080.5 range: 63741301..63764757

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005764	lysosome	Cellular Component	IEA
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	IEA
GO:0004213	cathepsin B activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0050790	regulation of catalytic activity	Biological Process	IEA