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Gene Information
Gene ID:13030
Symbol:Ctsb
Full Name:cathepsin B
Organism:Mus musculus (Mouse)
Chromosome:14
Genetic Location:14 D1|14 28.0 cM
Physical Location:63741301-63764757 on NC_000080.5
Gene Type:protein-coding
Human Ortholog:GeneID: 1508    Symbol (Name): CTSB (cathepsin B)
Ortholog Status:The human GeneID 1508 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ctsb
Dataset Information
Name:16618939
Method:Microarray
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Caws5/Alcw7Chronic Alcohol Withdrawal14 24-48 (cM)4.26.00E-05SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_007798.2NP_031824.1NC_000080.5 range: 63741301..63764757
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIDA (14651853)
GO:0005764lysosomeCellular ComponentIEA
GO:0004197cysteine-type endopeptidase activityMolecular FunctionIEA
GO:0004213cathepsin B activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0008234cysteine-type peptidase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006508proteolysisBiological ProcessIEA
GO:0050790regulation of catalytic activityBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:13030
MGI:
Ensembl:ENSMUSG00000021939
dbSNP:Ctsb
AceView:Ctsb