ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dad1

Full Name:

defender against cell death 1

Alias:

AI323713

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 C2|14 24.0 cM

Physical Location:

54859335-54873552 on NC_000080.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1603 Symbol (Name): DAD1 (defender against cell death 1)

Ortholog Status:

The human GeneID 1603 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Dad1

Dataset Information

Name:		16618939
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Alcohol preference
Publication:		Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:		Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (\|d\|) and lowest Q values.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws5/Alcw7	Chronic Alcohol Withdrawal	14		24-48 (cM)	4.2	6.00E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010015.4	NP_034145.1	NC_000080.5 range: 54859335..54873552, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	RCA (16141072)
GO:0008250	oligosaccharyl transferase complex	Cellular Component	RCA (16141072)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (16141072)
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006486	protein amino acid glycosylation	Biological Process	RCA (16141072)
GO:0006915	apoptosis	Biological Process	RCA (16141072)
GO:0006916	anti-apoptosis	Biological Process	RCA (16141072)