ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

13489

Symbol:

Drd2

Full Name:

dopamine receptor 2

Alias:

D2R|Drd-2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 A5.3|9 28.0 cM

Physical Location:

49148731-49216281 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1813 Symbol (Name): DRD2 (dopamine receptor D2)

Ortholog Status:

The human GeneID 1813 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap5q	Alcohol Preference Drinking	9	25	10-35 (cM)	4.8		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010077.2	NP_034207.2	NC_000075.5 range: 49148731..49216281

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030425	dendrite	Cellular Component	IDA (10051229)
GO:0016020	membrane	Cellular Component	IDA (7706278)
GO:0030424	axon	Cellular Component	IDA (10051229)
GO:0016020	membrane	Cellular Component	RCA (12466851)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0035240	dopamine binding	Molecular Function	IDA (15716360)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IDA (14712229)
GO:0004930	G-protein coupled receptor activity	Molecular Function	RCA (12466851)
GO:0004952	dopamine receptor activity	Molecular Function	IEA
GO:0001670	dopamine D2 receptor activity	Molecular Function	IMP (9140068\|9247268\|11069974\|11172060)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0001584	rhodopsin-like receptor activity	Molecular Function	IEA
GO:0001670	dopamine D2 receptor activity	Molecular Function	IDA (1980140\|1991517\|7566118\|7706278\|8836575\|11015197\|11069937\|12476322)
GO:0001591	dopamine D2 receptor-like receptor activity	Molecular Function	IMP (15721235)
GO:0001591	dopamine D2 receptor-like receptor activity	Molecular Function	IDA (8294904\|12930822)
GO:0030432	peristalsis	Biological Process	IMP (16525059)
GO:0042493	response to drug	Biological Process	IMP (16136297)
GO:0042493	response to drug	Biological Process	IDA (7549459)
GO:0042417	dopamine metabolic process	Biological Process	IMP (7925842)
GO:0042220	response to cocaine	Biological Process	IMP (11923462\|11943831\|12185400)
GO:0040018	positive regulation of multicellular organism growth	Biological Process	IMP (11897683)
GO:0060160	negative regulation of dopamine receptor signaling pathway	Biological Process	IMP (11089973)
GO:0032922	circadian regulation of gene expression	Biological Process	IMP (16606840)
GO:0030432	peristalsis	Biological Process	IGI (15272078)
GO:0032228	regulation of synaptic transmission, GABAergic	Biological Process	IGI (10934242)
GO:0048169	regulation of long-term neuronal synaptic plasticity	Biological Process	IMP (9169514)
GO:0030534	adult behavior	Biological Process	IMP (11303741)
GO:0032228	regulation of synaptic transmission, GABAergic	Biological Process	IMP (15080900\|15489038)
GO:0043266	regulation of potassium ion transport	Biological Process	IMP (11566895)
GO:0043278	response to morphine	Biological Process	IMP (9252189\|11264672\|11567069\|11943831\|12182883)
GO:0060134	prepulse inhibition	Biological Process	IMP (10341260\|12417685\|12476322)
GO:0060158	dopamine receptor, phospholipase C activating pathway	Biological Process	IDA (15016423)
GO:0060158	dopamine receptor, phospholipase C activating pathway	Biological Process	IGI (17194762)
GO:0060158	dopamine receptor, phospholipase C activating pathway	Biological Process	ISO
GO:0051967	negative regulation of synaptic transmission, glutamatergic	Biological Process	IMP (11160501\|15489038)
GO:0051898	negative regulation of protein kinase B signaling cascade	Biological Process	IMP (17251429)
GO:0051586	positive regulation of dopamine uptake	Biological Process	IMP (9886065)
GO:0051584	regulation of dopamine uptake	Biological Process	IMP (12223553)
GO:0050804	regulation of synaptic transmission	Biological Process	IMP (10974427)
GO:0048755	branching morphogenesis of a nerve	Biological Process	IMP (11438590)
GO:0060160	negative regulation of dopamine receptor signaling pathway	Biological Process	IGI (12097513)
GO:0048149	behavioral response to ethanol	Biological Process	IMP (11105945\|11166059\|12837020)
GO:0048148	behavioral response to cocaine	Biological Process	IMP (17426149)
GO:0045776	negative regulation of blood pressure	Biological Process	IMP (11566895)
GO:0043473	pigmentation	Biological Process	IMP (9140068)
GO:0060124	positive regulation of growth hormone secretion	Biological Process	IMP (11897683)
GO:0030336	negative regulation of cell migration	Biological Process	IMP (17409246)
GO:0007409	axonogenesis	Biological Process	IMP (11438590)
GO:0007270	nerve-nerve synaptic transmission	Biological Process	IMP (12084937)
GO:0007212	dopamine receptor signaling pathway	Biological Process	IGI (11089973)
GO:0007195	dopamine receptor, adenylate cyclase inhibiting pathway	Biological Process	IMP (7706278)
GO:0007195	dopamine receptor, adenylate cyclase inhibiting pathway	Biological Process	IGI (7706278\|12223546)
GO:0007195	dopamine receptor, adenylate cyclase inhibiting pathway	Biological Process	IDA (12665504)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	RCA (12466851)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IDA (14712229)
GO:0007165	signal transduction	Biological Process	IEA
GO:0002052	positive regulation of neuroblast proliferation	Biological Process	IDA (17426594)
GO:0002028	regulation of sodium ion transport	Biological Process	IMP (11566895)
GO:0002027	regulation of heart rate	Biological Process	IMP (11566895)
GO:0001976	regulation of systemic arterial blood pressure by neurological process	Biological Process	IMP (11566895)
GO:0001975	response to amphetamine	Biological Process	IMP (12476322)
GO:0001975	response to amphetamine	Biological Process	IGI (12097513)
GO:0007608	sensory perception of smell	Biological Process	IMP (16765459)
GO:0007625	grooming behavior	Biological Process	IMP (10698004)
GO:0030147	natriuresis	Biological Process	IMP (11566895)
GO:0030146	diuresis	Biological Process	IMP (11566895)
GO:0021984	adenohypophysis development	Biological Process	IMP (9140068)
GO:0021853	cerebral cortex GABAergic interneuron migration	Biological Process	IMP (17409246)
GO:0007628	adult walking behavior	Biological Process	IMP (7566118)
GO:0014059	regulation of dopamine secretion	Biological Process	IMP (11943831)
GO:0009416	response to light stimulus	Biological Process	IMP (16715079)
GO:0008542	visual learning	Biological Process	IMP (12097513)
GO:0008306	associative learning	Biological Process	IMP (12084937\|12182883\|15061865)
GO:0008285	negative regulation of cell proliferation	Biological Process	IMP (9140068\|9247267\|9247268\|9717839\|10537166)
GO:0008285	negative regulation of cell proliferation	Biological Process	IGI (9247268)
GO:0008104	protein localization	Biological Process	IMP (10828532)
GO:0007631	feeding behavior	Biological Process	IGI (15272078)
GO:0007626	locomotory behavior	Biological Process	IMP (9547254\|10471093\|10698004\|11069937\|11166059\|11557166\|12084937\|12175868\|12185400\|12837020\|15080900)
GO:0007626	locomotory behavior	Biological Process	IGI (9354330\|10908627\|11150348\|11172060\|11864730\|15272078\|16280580)
GO:0001659	temperature homeostasis	Biological Process	IMP (10471093)