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Gene Information
Gene ID:135
Symbol:ADORA2A
Full Name:adenosine A2a receptor
Alias:ADORA2|RDC8|hA2aR
Organism:Homo sapiens (Human)
Chromosome:22
Genetic Location:22q11.23
Physical Location:23153529-23168324 on NC_000022.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original IDNo. of PublicationsPhenotype
ADORA2A1Alcoholism
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000675.4NP_000666.2NC_000022.9 range: 23153529..23168324
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentTAS (10051547)
GO:0005886plasma membraneCellular ComponentTAS (8794889|10051547)
GO:0005887integral to plasma membraneCellular ComponentTAS (8794889)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0016519gastric inhibitory peptide receptor activityMolecular FunctionNAS (8522976)
GO:0001609adenosine receptor activity, G-protein coupledMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0006171cAMP biosynthetic processBiological ProcessTAS (10899090)
GO:0007190activation of adenylate cyclase activityBiological ProcessNR
GO:0007267cell-cell signalingBiological ProcessTAS (7818494)
GO:0007417central nervous system developmentBiological ProcessTAS (10945659)
GO:0007596blood coagulationBiological ProcessTAS (10899090)
GO:0007600sensory perceptionBiological ProcessTAS (9262401)
GO:0008015blood circulationBiological ProcessTAS (9262401)
GO:0007190activation of adenylate cyclase activityBiological ProcessEXP (16805430)
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerBiological ProcessTAS (10899090)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessEXP (16939974)
GO:0006968cellular defense responseBiological ProcessTAS (10051547)
GO:0006954inflammatory responseBiological ProcessTAS (8360491)
GO:0006915apoptosisBiological ProcessTAS (7818494)
GO:0006909phagocytosisBiological ProcessTAS (8360491)
GO:0006836neurotransmitter transportBiological ProcessNAS (8522976)
GO:0007165signal transductionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:135
HGNC:263
Ensembl:ENSG00000128271
MIM:102776
HPRD:00043
HuGE Navigator:135
dbSNP:ADORA2A
GeneCard:ADORA2A
AceView:ADORA2A