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Gene Information
Gene ID:136
Symbol:ADORA2B
Full Name:adenosine A2b receptor
Alias:ADORA2
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17p12-p11.2
Physical Location:15788955-15819934 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D17S1857  16355942
Region:14355942-18355942
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000676.2NP_000667.1NC_000017.9 range: 15788955..15819934
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (7558011)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0001609adenosine receptor activity, G-protein coupledMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0000187activation of MAPK activityBiological ProcessTAS (10101031)
GO:0007254JNK cascadeBiological ProcessTAS (10101031)
GO:0007190activation of adenylate cyclase activityBiological ProcessTAS (8022409)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (7558011)
GO:0007165signal transductionBiological ProcessIEA
GO:0006968cellular defense responseBiological ProcessTAS (10101031)
GO:0007588excretionBiological ProcessTAS (7836474)
Other Database Cross Links
NCBI Entrez Gene:136
HGNC:264
Ensembl:ENSG00000170425
MIM:600446
HPRD:15971
HuGE Navigator:136
dbSNP:ADORA2B
GeneCard:ADORA2B
AceView:ADORA2B