ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Hnmt

Full Name:

histamine N-methyltransferase

Alias:

1500031F01Rik|AI788969

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 A3

Physical Location:

23858430-23904898 on NC_000068.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3176 Symbol (Name): HNMT (histamine N-methyltransferase)

Ortholog Status:

The human GeneID 3176 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hnmt
Fold Change:		1.79
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080462.2	NP_536710.1	NC_000068.6 range: 23858430..23904898, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0008168	methyltransferase activity	Molecular Function	RCA (12466851)
GO:0008170	N-methyltransferase activity	Molecular Function	IDA (11475331)
GO:0016740	transferase activity	Molecular Function	RCA (12466851)
GO:0001505	regulation of neurotransmitter levels	Biological Process	TAS (11475331)