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Gene Information
Gene ID:140483
Full Name:histamine N-methyltransferase
Organism:Mus musculus (Mouse)
Genetic Location:2 A3
Physical Location:23858430-23904898 on NC_000068.6, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3176    Symbol (Name): HNMT (histamine N-methyltransferase)
Ortholog Status:The human GeneID 3176 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hnmt
Fold Change:1.79
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_080462.2NP_536710.1NC_000068.6 range: 23858430..23904898, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0005737cytoplasmCellular ComponentIEA
GO:0008168methyltransferase activityMolecular FunctionRCA (12466851)
GO:0008170N-methyltransferase activityMolecular FunctionIDA (11475331)
GO:0016740transferase activityMolecular FunctionRCA (12466851)
GO:0001505regulation of neurotransmitter levelsBiological ProcessTAS (11475331)
Other Database Cross Links
NCBI Entrez Gene:140483