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Gene Information
Gene ID:140559
Symbol:Igsf8
Full Name:immunoglobulin superfamily, member 8
Alias:AA033172|AU041109|ESTM34|EWI-2|KCT-4|PGRL|R75384
Organism:Mus musculus (Mouse)
Chromosome:1
Genetic Location:1 H3|1 94.2 cM
Physical Location:174242537-174249967 on NC_000067.5
Gene Type:protein-coding
Human Ortholog:GeneID: 93185    Symbol (Name): IGSF8 (immunoglobulin superfamily, member 8)
Ortholog Status:The human GeneID 93185 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Igsf8
Dataset Information
Name:16618939
Method:Microarray
Tissue:Whole brain
Phenotype:Alcohol preference
Publication:Mulligan et al. Proc Natl Acad Sci U S A. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PubMed
Summary:Microarray analyses of brain gene expression in three selected lines, and six isogenic strains of mice known to differ markedly in voluntary alcohol consumption provided >4.5 million data points for a meta-analysis. A total of 107 arrays were obtained and arranged into six experimental data sets, allowing the identification of 3,800 unique genes significantly and consistently changed between all models of high or low amounts of alcohol consumption. Here we select the 75 genes with the largest effect size (|d|) and lowest Q values.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcw1Acute Alcohol Withdrawal196172.3-176.5 (Mb)5.63.00E-07SignificantPARC
Calw1/Alcdp1Chronic Alcohol Withdrawal19689-106.3 (cM)7.62.00E-09SignificantPARC
Ap1qAlcohol Preference Drinking17645-95 (cM)4.5 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_080419.1NP_536344.1NC_000067.5 range: 174242537..174249967
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentISS (11504738)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0005515protein bindingMolecular FunctionIDA (11504738)
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:140559
MGI:
Ensembl:ENSMUSG00000038034
dbSNP:Igsf8
AceView:Igsf8