ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

14130

Symbol:

Fcgr2b

Full Name:

Fc receptor, IgG, low affinity IIb

Alias:

AI528646|CD32|F630109E10Rik|Fc[g]RII|FcgRII|Fcgr2|Fcgr2a|Fcr-2|Fcr-3|Ly-17|Ly-m20|LyM-1|Lym-1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H3|1 92.3 cM

Physical Location:

172890688-172906201 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2213 Symbol (Name): FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))

Ortholog Status:

The human GeneID 2213 is not in current human dataset.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001077189.1	NP_001070657.1	NC_000067.5 range: 172890688..172906201, complement
NM_010187.2	NP_034317.1	NC_000067.5 range: 172890688..172906201, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IDA (8552190)
GO:0016020	membrane	Cellular Component	IEA
GO:0009897	external side of plasma membrane	Cellular Component	IDA (8552190\|8769481)
GO:0005887	integral to plasma membrane	Cellular Component	IC (8552190)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (12893283)
GO:0005057	receptor signaling protein activity	Molecular Function	TAS (11994421)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0019864	IgG binding	Molecular Function	IDA (9551950)
GO:0050766	positive regulation of phagocytosis	Biological Process	IDA (8769481)
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Biological Process	IMP (14643301)
GO:0030889	negative regulation of B cell proliferation	Biological Process	IMP (8552190)
GO:0045576	mast cell activation	Biological Process	IDA (8769481)
GO:0001811	negative regulation of type I hypersensitivity	Biological Process	IMP (8552190)
GO:0016064	immunoglobulin mediated immune response	Biological Process	IMP (10395649\|14643301)
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IMP (8552190)
GO:0006955	immune response	Biological Process	IMP (11994421)
GO:0006952	defense response	Biological Process	IMP (11994421)
GO:0006911	phagocytosis, engulfment	Biological Process	IDA (8769481)
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Biological Process	IMP (16492738)
GO:0050777	negative regulation of immune response	Biological Process	IMP (8552190\|10395649)