ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fcgr3

Full Name:

Fc receptor, IgG, low affinity III

Alias:

CD16

Organism:

Mus musculus (Mouse)

Chromosome:

1

Genetic Location:

1 H3|1 92.3 cM

Physical Location:

172981325-172989528 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Alcw1	Acute Alcohol Withdrawal	1	96	172.3-176.5 (Mb)	5.6	3.00E-07	Significant	PARC
Calw1/Alcdp1	Chronic Alcohol Withdrawal	1	96	89-106.3 (cM)	7.6	2.00E-09	Significant	PARC
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010188.5	NP_034318.2	NC_000067.5 range: 172981325..172989528, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0019864	IgG binding	Molecular Function	IMP (9743367\|9834201)
GO:0019770	IgG receptor activity	Molecular Function	IMP (9743367\|9834201)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0045576	mast cell activation	Biological Process	IDA (8552190)
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process	IMP (11911824)
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	Biological Process	IMP (10229794)
GO:0045576	mast cell activation	Biological Process	IMP (8769481)
GO:0050766	positive regulation of phagocytosis	Biological Process	IMP (8769481\|9743367\|9834201)
GO:0030593	neutrophil chemotaxis	Biological Process	IMP (11420040)
GO:0001788	antibody-dependent cellular cytotoxicity	Biological Process	IMP (8769481\|9743367)
GO:0001798	positive regulation of type IIa hypersensitivity	Biological Process	IMP (9834201\|11911824)
GO:0001805	positive regulation of type III hypersensitivity	Biological Process	IMP (8769481)
GO:0001812	positive regulation of type I hypersensitivity	Biological Process	IDA (8552190)
GO:0001812	positive regulation of type I hypersensitivity	Biological Process	IMP (8769481\|9743367)
GO:0001820	serotonin secretion	Biological Process	IDA (8552190)
GO:0006910	phagocytosis, recognition	Biological Process	IMP (8769481\|9743367\|9834201)
GO:0006911	phagocytosis, engulfment	Biological Process	IMP (8769481\|9743367\|9834201)
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IMP (8769481)
GO:0050776	regulation of immune response	Biological Process	IMP (11911824)

Other Database Cross Links

NCBI Entrez Gene:

MGI:

Ensembl:

ENSMUSG00000059498

dbSNP:

AceView: