ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fzd3

Full Name:

frizzled homolog 3 (Drosophila)

Alias:

AU020229|Fz3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

14 D1|14 27.0 cM

Physical Location:

65821235-65872263 on NC_000080.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7976 Symbol (Name): FZD3 (frizzled homolog 3 (Drosophila))

Ortholog Status:

The human GeneID 7976 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fzd3
Fold Change:		1.68
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws5/Alcw7	Chronic Alcohol Withdrawal	14		24-48 (cM)	4.2	6.00E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021458.1	NP_067433.1	NC_000080.5 range: 65821235..65872263, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045177	apical part of cell	Cellular Component	IDA (16495441\|16687519)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016020	membrane	Cellular Component	IEA
GO:0004926	non-G-protein coupled 7TM receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16687519)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0016055	Wnt receptor signaling pathway	Biological Process	IEA
GO:0042472	inner ear morphogenesis	Biological Process	IGI (16495441)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007166	cell surface receptor linked signal transduction	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0001843	neural tube closure	Biological Process	IGI (16495441)
GO:0001736	establishment of planar polarity	Biological Process	IGI (16495441)