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Gene Information
Gene ID:14365
Symbol:Fzd3
Full Name:frizzled homolog 3 (Drosophila)
Alias:AU020229|Fz3
Organism:Mus musculus (Mouse)
Chromosome:14
Genetic Location:14 D1|14 27.0 cM
Physical Location:65821235-65872263 on NC_000080.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7976    Symbol (Name): FZD3 (frizzled homolog 3 (Drosophila))
Ortholog Status:The human GeneID 7976 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Fzd3
Fold Change:1.68
Note:Significantly regulated by ethanol in cortical neurons
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Caws5/Alcw7Chronic Alcohol Withdrawal14 24-48 (cM)4.26.00E-05SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_021458.1NP_067433.1NC_000080.5 range: 65821235..65872263, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045177apical part of cellCellular ComponentIDA (16495441|16687519)
GO:0016021integral to membraneCellular ComponentRCA (12466851)
GO:0005615extracellular spaceCellular ComponentRCA (12466851)
GO:0016020membraneCellular ComponentIEA
GO:0004926non-G-protein coupled 7TM receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (16687519)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0004930G-protein coupled receptor activityMolecular FunctionIEA
GO:0016055Wnt receptor signaling pathwayBiological ProcessIEA
GO:0042472inner ear morphogenesisBiological ProcessIGI (16495441)
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007166cell surface receptor linked signal transductionBiological ProcessIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0001843neural tube closureBiological ProcessIGI (16495441)
GO:0001736establishment of planar polarityBiological ProcessIGI (16495441)
Other Database Cross Links
NCBI Entrez Gene:14365
MGI:
Ensembl:ENSMUSG00000007989
dbSNP:Fzd3
AceView:Fzd3