ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC25A10

Full Name:

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

Alias:

DIC

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25.3

Physical Location:

77289775-77298446 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S928

77846128

Region:		75846128-78774742
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012140.3	NP_036272.2	NC_000017.9 range: 77289775..77298446

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005310	dicarboxylic acid transmembrane transporter activity	Molecular Function	TAS (9733776)
GO:0005488	binding	Molecular Function	IEA
GO:0006094	gluconeogenesis	Biological Process	TAS (9733776)
GO:0006835	dicarboxylic acid transport	Biological Process	TAS (9733776)
GO:0006839	mitochondrial transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA