ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gnb2

Full Name:

guanine nucleotide binding protein (G protein), beta 2

Alias:

Gnb-2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

5 G2|5 76.0 cM

Physical Location:

137969356-137974456 on NC_000071.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2783 Symbol (Name): GNB2 (guanine nucleotide binding protein (G protein), beta polypeptide 2)

Ortholog Status:

The human GeneID 2783 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gnb2
Fold Change:		0.69
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Gnb2
Fold Change:		0.67
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_010312.4	NP_034442.1	NC_000071.5 range: 137969356..137974456, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005834	heterotrimeric G-protein complex	Cellular Component	ISS (1543505)
GO:0003924	GTPase activity	Molecular Function	ISS (1543505)
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11591653)
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	TAS (1543505)