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Gene Information
Gene ID:14693
Symbol:Gnb2
Full Name:guanine nucleotide binding protein (G protein), beta 2
Alias:Gnb-2
Organism:Mus musculus (Mouse)
Chromosome:5
Genetic Location:5 G2|5 76.0 cM
Physical Location:137969356-137974456 on NC_000071.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2783    Symbol (Name): GNB2 (guanine nucleotide binding protein (G protein), beta polypeptide 2)
Ortholog Status:The human GeneID 2783 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Gnb2
Fold Change:0.69
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Gnb2
Fold Change:0.67
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010312.4NP_034442.1NC_000071.5 range: 137969356..137974456, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005834heterotrimeric G-protein complexCellular ComponentISS (1543505)
GO:0003924GTPase activityMolecular FunctionISS (1543505)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (11591653)
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (1543505)
Other Database Cross Links
NCBI Entrez Gene:14693
MGI:
Ensembl:ENSMUSG00000029713
dbSNP:Gnb2
AceView:Gnb2